Toward the natural didemnaketal A: total synthesis of the isomer of didemnaketal A |
| |
Authors: | Lei Peng Fu-Min ZhangBing-Miao Yang Xiao-Bo ZhangWen-Xing Liu Shu-Yu ZhangYong-Qiang Tu |
| |
Affiliation: | State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University, Lanzhou 730000, PR China |
| |
Abstract: | The total synthesis of isomer of didemnaketal A was achieved in 26 steps. The position of esters is switched at C7 and C8 with respect to their proposed position in natural didemnaketal A, which shows potent anti-HIV activity but so far has not been synthesized in the laboratory. Structural analysis of synthetic isomer of didemnaketal A indicates that the esters at C7 and C8 are correctly assigned, suggesting that the problems for the structural reassignment of natural didemnaketal A lie elsewhere. |
| |
Keywords: | Didemnaketal A Total synthesis Isomer Structural reassignment |
本文献已被 ScienceDirect 等数据库收录! |