Preyssler catalyst-promoted rapid,clean, and efficient condensation reactions for 3H-1,5-benzodiazepine synthesis in solvent-free conditions |
| |
Authors: | Gustavo A. Pasquale Diego M. Ruiz Jorge L. Jios Juan C. Autino Gustavo P. Romanelli |
| |
Affiliation: | 1. Centro de Investigación y Desarrollo en Ciencias Aplicadas ‘Dr. Jorge J. Ronco’ (CINDECA-CCT-CONICET), Universidad Nacional de La Plata, Calle 47 N° 257, B1900AJK La Plata, Argentina;2. Cátedra de Química Orgánica, Facultad de Ciencias Agrarias y Forestales, Universidad Nacional de La Plata/CISaV, Calles 60 y 119 s/n, B1904AAN La Plata, Argentina;3. Unidad Laseisic-Plapimu (UNLP-CIC), Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 47 esq. 115, (1900) La Plata, Argentina |
| |
Abstract: | A simple, convenient, and environmentally benign synthesis of 1,5-benzodiazepines is developed by condensing different o-phenylenediamines and 1,3-aryl-1,3-propanodiones. The reaction is catalyzed by a Preyssler (NaH14P5W30O110, HPA) heteropolyacid as a safe, clean, and recyclable catalyst. The method is operationally simple and provides access to a variety of 1,5-benzodiazepines in good to excellent yields. |
| |
Keywords: | 3H-1,5-Benzodiazepines o-Phenylenediamine 1,3-Diaryl-1,3-propanediones Preyssler catalyst Solvent-free |
本文献已被 ScienceDirect 等数据库收录! |
|