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Stereoselective synthesis of (S)-dapoxetine: a chiral auxiliary mediated approach |
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| Authors: | Gopal L Khatik Ratnesh Sharma Varun Kumar Mangilal Chouhan Vipin A Nair |
| Institution: | 1. Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Lovely Professional University, G.T. Road, Phagwara, Punjab 144402, India;2. Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, Mohali, Punjab 160062, India |
| Abstract: | An imidazolidin-2-one chiral auxiliary mediated acetate aldol reaction was explored in the enantioselective synthesis of (S)-dapoxetine (SSRI). The diastereoselective aldol adduct was transformed to highly enantiopure (S)-dapoxetine with overall good yield. |
| Keywords: | Asymmetric reaction Acetate aldol Dapoxetine Chiral auxiliary |
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