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Condensation of Vilsmeier salts,derived from tetraalkylureas,with amidoximes: a novel approach to access N,N-dialkyl-1,2,4-oxadiazol-5-amines |
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| Authors: | Dongshan Su Haifeng Duan Zhonglin Wei Jungang Cao Dapeng Liang Yingjie Lin |
| Institution: | 1. Department of Chemistry, Jilin University, Changchun 130012, PR China;2. Department of Environment and Resources, Jilin University, Changchun 130012, PR China |
| Abstract: | A novel approach, condensation of Vilsmeier salts and amidoximes, to access N,N-dialkyl-1,2,4-oxadiazol-5-amines has been developed. By this approach, a broad range of N,N-dialkyl-1,2,4-oxadiazol-5-amines, including aromatic, heteroaromatic, and aliphatic substituents, can be synthesized in good to high yields (up to 82%) under mild reaction conditions. |
| Keywords: | PRGBJPOYMDRRCW-UHFFFAOYSA-N JYGUDSIRIANHGH-UHFFFAOYSA-N OAFARKCBOYPGKF-UHFFFAOYSA-N KYIJGIGGCNNKSK-UHFFFAOYSA-N QAVCDHOIQRUYAQ-UHFFFAOYSA-N UKSHJSZSTYQCLH-UHFFFAOYSA-N XKLOTBJESPOLBK-UHFFFAOYSA-N SHCSZQLSYOZNSW-UHFFFAOYSA-N OXLSRTUSBWOFMP-UHFFFAOYSA-M WXKJEJABBWADEE-UHFFFAOYSA-N LZHPRUHZLNDTMW-UHFFFAOYSA-N WAOMFCVNHLPGIQ-UHFFFAOYSA-N CHBVWNNWOTUVFM-UHFFFAOYSA-N VUOHXRLEFCNHRX-UHFFFAOYSA-N KWTZNHYQWVJVRJ-UHFFFAOYSA-N UBLHEMHOMXFQKF-UHFFFAOYSA-N YFYGJRXCLORTGH-UHFFFAOYSA-N GMIRHSLUNITSII-UHFFFAOYSA-N ABZUDWBPUHPFSS-UHFFFAOYSA-N GBFATDAXTHHBGW-UHFFFAOYSA-N |
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