|
|||||
|
|
A solvent-free amidation of vinylogous esters via direct aziridination |
|
| Authors: | Emily C. McLaughlin Anuska ShresthaMadison H. Fletcher Nathaniel S. SteinauerMin Kyung Shinn Sabrina M. Shahid |
| Affiliation: | Bard College, 30 Campus Road, Annandale-on-Hudson, NY 12504, United States |
| Abstract: | A microwave-mediated aziridination of α,β-unsaturated ketones and esters through the decomposition of ethyl azidoformate has been developed. When the same atom-economical reaction conditions are applied to cyclic vinylogous esters, N-functionalization at the α-position occurs. Based on NMR analysis, these amidation products appear to be formed from the desired aziridine in moderate to good yields. |
| Keywords: | Aziridination Ethyl azidoformate Microwave-mediated synthesis Vinylogous ester Amidation |
| 本文献已被 ScienceDirect 等数据库收录！ | |