Synthesis of polysubstituted pyridines via reactions of chalcones and malononitrile in alcohols using Amberlite IRA-400 (OH) |
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| Authors: | Kiumars Bahrami Mohammad M. Khodaei Fardin Naali Behrooz H. Yousefi |
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| Affiliation: | 1. Department of Organic Chemistry, Faculty of Chemistry, Razi University, Kermanshah 67149-67346, Iran;2. Pharmaceutical Radiochemistry, Faculties of Chemistry and Medicine, Technische Universität München, Walther-Meißner-Str. 3, 85748 Garching, Germany |
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| Abstract: | Polysubstituted pyridine derivatives were synthesized through economical one-pot multicomponent reactions of different α,β-unsaturated ketones, malononitrile, and ethanol or methanol in the presence of Amberlite IRA-400 (OH−) at room temperature. The catalyst is recyclable several times without substantial loss of activity. Other valuable features include the wide range of functional group tolerance, easy and clean synthesis with a simple work-up procedure, and excellent yields under mild conditions. |
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| Keywords: | Polysubstituted pyridine Ion-exchange resin Multicomponent reaction Chalcones Malononitrile Solid base catalyst |
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