One-pot three-component synthesis of indole-3-glyoxyl derivatives and indole-3-glyoxyl triazoles |
| |
| Authors: | Hé lio A. Stefani,Stanley N.S. Vasconcelos,Frederico B. Souza,Flá via Manarin,Julio Zukerman-Schpector |
| |
| Affiliation: | 1. Departamento de Farmácia, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, SP, Brazil;2. Departamento de Química, Universidade Federal de São Carlos, SP, Brazil |
| |
| Abstract: | A general and efficient reaction of indole with oxalyl chloride and nucleophiles providing indole-3-glyoxyl derivatives has been developed in mild conditions. In the same fashion, the other reaction involved the addition of organic azides leading to the synthesis of indole-3-glyoxyl-1,2,3-triazoles, which proceeds smoothly generating the products in moderate to high yields. |
| |
| Keywords: | Indole Oxalyl chloride Nucleophiles Triazole Multicomponent reactions (MCRs) |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
