Beneficial effect of carboxylic acid additives on the Pd-catalyzed intramolecular N-arylation of 2-amino-3-(2-chlorophenylsulfonyl)pyrroles |
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| Authors: | Perounsack X Moon Chad E Stephens |
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| Institution: | Department of Chemistry and Physics, Georgia Regents University, Augusta, GA 30904, USA |
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| Abstract: | Carboxylic acid additives have been shown to significantly improve the yield of the Pd-catalyzed intramolecular N-arylation of 2-aminopyrroles containing a 2-chlorophenylsulfonyl group at the 3-position to give a novel tricyclic ring system. Pivalic and phenylacetic acid provided the best yield enhancement, while acetic acid showed moderate enhancement. Other acids showed limited to no enhancement or even a detrimental effect on the reaction. |
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| Keywords: | Buchwald&ndash Hartwig reaction Intramolecular N-arylation 2-Aminopyrrole Carboxylic acid additive Pyrrolo[3 2-b]benzo[1 4]thiazine |
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