A straightforward synthesis of indazolo[3,2-a]isoquinolin-6-amines |
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| Authors: | Jó zsef Balog,Zsuzsanna RiedlGyö rgy Hajó s |
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| Affiliation: | Research Center for Natural Sciences, Institute of Organic Chemistry, Hungarian Academy of Sciences, Pusztaszeri út 59, H-1025 Budapest, Hungary |
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| Abstract: | 4-Substituted 1-bromoisoquinolin-3-amines were subjected to Suzuki coupling with o-nitrophenylboronic acid to yield 1-(2-nitrophenyl) isoquinolinamines, which participated in Cadogan cyclization with triethyl phosphite under microwave irradiation in a sealed vial to yield fluorescent indazolo[3,2-a]isoquinolin-6-amines. The new compounds were also functionalized by transformation of the amino group. |
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| Keywords: | Suzuki coupling Nitrene Indazole Cyclization Fluorescence |
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