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Regioselective 2′-O-debenzoylation of 2',3'-di-O-benzoyl threose nucleosides
Authors:Mi-Yeon Jang  Matheus FroeyenPiet Herdewijn
Affiliation:Medicinal Chemistry, Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, 3000 Leuven, Belgium
Abstract:A simple and convenient procedure for the regioselective 2′-O-debenzoylation of 2',3'-di-O-benzoyl threose nucleosides has been achieved successfully affording 3′-O-benzoyl threose nucleosides, which are useful starting material synthons for the synthesis of modified threose nucleosides for different purposes.
Keywords:Threose   Regioselective debenzoylation   Potassium tert-butoxide   TNA   2&prime  -Modified threose nucleosides
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