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Direct asymmetric Michael addition of phthalide derivatives to chalcones |
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| Authors: | Jie Luo Chunhui Jiang Haifei Wang Li-Wen Xu Yixin Lu |
| Affiliation: | 1. Department of Chemistry and Medicinal Chemistry Program, Life Sciences Institute, National University of Singapore, 3 Science Drive 3, Singapore 117543, Republic of Singapore;2. Hunan University of Technology, Hunan 412008, PR China;3. Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, Hangzhou 310012, PR China |
| Abstract: | The Michael addition of phthalides to chalcones employing a quinidine-derived thiourea catalyst Q-1 has been developed. The reported method led to the synthesis of 3,3-disubstituted phthalide derivatives in excellent yields, with excellent diastereo- and enantioselectivities. |
| Keywords: | Michael addition Phthalide derivatives Chalcones Organocatalysis Quinine thiourea catalyst |
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