A general,flexible, ring closing metathesis (RCM) based strategy for accessing the fused furo[3,2-b]furanone moiety present in diverse bioactive natural products |
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| Authors: | Ali Mohd Lone Bilal Ahmad Bhat Goverdhan Mehta |
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| Institution: | 1. Indian Institute of Integrative Medicine (CSIR), Sanatnagar, Srinagar 190005, India;2. School of Chemistry, University of Hyderabad, Hyderabad 500046, India |
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| Abstract: | A simple and straightforward methodology of general utility to construct sterically encumbered furo3,2-b]furanone scaffolds present in a diverse range of bioactive natural products is delineated. The methodology emanates from readily available Morita–Baylis–Hillman adducts and employs sequential ring closing metathesis and oxy-Michael addition cascade as the key steps. |
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| Keywords: | Ring closing metathesis Furo[3 2-b]furanone Natural products Baylis&ndash Hillman adducts Sterically encumbered |
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