Additional cytotoxic substances isolated from the sponge-derived Gymnascella dankaliensis |
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| Authors: | Taro Amagata Makoto Tanaka Takeshi Yamada Yi-Pei Chen Katsuhiko Minoura Atsushi Numata |
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| Affiliation: | 1. Department of Chemistry and Biochemistry, San Francisco State University, San Francisco, CA 94132, USA;2. Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan |
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| Abstract: | A continuous investigation of secondary metabolites produced by the sponge-derived fungus, Gymnascella dankaliensis, has yielded a new polyketide tyrosine derivative, dankastatin C (3) and the known steroid, demethylincisterol A3 (4), which was originally found from a Homaxinella marine sponge. The stereostructure of the new compound has been determined based on the analysis of 1D and 2D NMR data. Dankastatin C (3) showed potent cell growth inhibitory activity against the murine P388 cell line. |
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| Keywords: | Marine-derived fungi Gymnascella dankaliensis Dankastain Cytotoxic secondary metabolites |
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