Green access to novel spiro pyranopyrazole derivatives |
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Authors: | DM Pore PB PatilDS Gaikwad PG HegadeJD Patil KA Undale |
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Institution: | Department of Chemistry, Shivaji University, Kolhapur 416 004, India |
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Abstract: | A catalyst-free multicomponent reaction (MCR) capable of affording a wide range of novel spiro pyranopyrazole derivatives from pyrazolone in situ formed from acetylenic esters with hydrazine hydrate at room temperature with isatin and malononitrile is reported. A plausible mechanism is suggested. Catalyst-free conditions along with green solvent system make the process ecofriendly as well as economical. Simple reaction conditions and easy work-up procedure that resulted into simple isolation and purification of products by non-chromatographic methods, that is, by simple recrystallization from methanol as well as novelty are the significant advantages of the present protocol. |
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Keywords: | Knoevenagel condensation Multicomponent Catalyst-free Economical Spiro pyranopyrazoles |
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