Nickel(0)/NaHMDS adduct-mediated intramolecular alkylation of unactivated arenes via a homolytic aromatic substitution mechanism |
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| Authors: | Louis-Philippe B Beaulieu Daniela Sustac Roman Frédéric Vallée André B Charette |
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| Affiliation: | FRQNT Centre in Green Chemistry and Catalysis, Department of Chemistry, Université de Montréal, PO Box 6128, Station Downtown, Montréal, Québec, Canada H3C 3J7. |
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| Abstract: | A variety of polycycles can be synthesized via an intramolecular alkylation cyclization promoted by Ni(PPh(3))(4) and NaHMDS. Mechanistic investigations support the catalytic nature of Ni(0) in the course of TEMPO scavenging experiments and its association with the substrate and NaHMDS to form an adduct by DOSY NMR. |
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