Antioxidant and anti-nitric oxide components from Quercus glauca |
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Authors: | Chien-Chang Shen Kun-Yuan Hong Jennifer Chen Li-Jie Zhang Zhi-Hu Lin Hung-Tse Huang Hui-Ling Cheng Yao-Haur Kuo |
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Institution: | National Research Institute of Chinese Medicine, Taipei 112, Taiwan, ROC. |
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Abstract: | From the ethanolic extract of Quercus glauca, two new lignans, (+)-5'-methoxyisolariciresinol-9'-O-α-L-rhamnopyranoside (1) and (7R,8S)-dihydrodehydrodiconiferyl alcohol 4-β-D-xyloside (2), along with fourteen known compounds including four lignanoids (3-6), five triterpenoids (7-11), two flavonoids (12, 13), two aromatics (14, 15), and one steroid (16) were isolated. The structures of the new compounds were elucidated on the basis of spectroscopic analysis. Moreover, compounds 9 and 14 strongly inhibited nitric oxide (NO) production with IC50 values of 8.25 and 14.04?μM, respectively, and compounds 1, 4-6, 14, and 15 showed moderate antioxidant activities. |
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