Stereoselective total synthesis of atpenins a4 and b, harzianopyridone, and NBRI23477 B |
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| Authors: | Masaki Ohtawa Kouhei Sugiyama Tohru Hiura Shujiro Izawa Kazuro Shiomi Satoshi Omura Tohru Nagamitsu |
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| Institution: | Graduate School of Pharmaceutical Sciences, Kitasato University, 5–9–1 Shirokane, Minato-ku, Tokyo, Japan. |
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| Abstract: | The stereoselective total synthesis of atpenins A4 (2) and B (3), harzianopyridone (4), and NBRI23477 B (5) have been developed using a convergent approach involving the coupling reaction of a common iodopyridine with an aldehyde corresponding to the appropriate side chain of the desired compound. Furthermore, the absolute configurations of atpenin B (3), harzianopyridone (4), and NBRI23477 B (5) have been unambiguously determined. |
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