Antibacterial properties of Ag-doped hydroxyapatite layers prepared by PLD method |
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| Authors: | Miroslav Jelínek Tomá? Kocourek Karel Jurek Jan Remsa Jan Mik?ovsky Marie Weiserová Jakub Strnad Thomas Luxbacher |
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| Institution: | (1) Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai, 201800, China;(2) Graduate school of Chinese Academy of Science, Beijing, 100039, China;(3) Shanghai Institute of Ceramics, Chinese Academy of Science, Shanghai, 200050, China;(4) Department of Physics, Nanjing University, Nanjing, 210093, China |
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| Abstract: | Thin hydroxyapatite (HA), silver-doped HA and silver layers were prepared using a pulsed laser deposition method. Doped layers
were ablated from silver/HA targets. Amorphous and crystalline films of silver concentrations of 0.06 at.%, 1.2 at.%, 4.4
at.%, 8.3 at.% and 13.7 at.% were synthesized. Topology was studied using scanning electron microscopy and atomic force microscopy.
Contact angle and zeta potential measurements were conducted to determine the wettability, surface free energy and electric
surface properties. In vivo measurement (using Escherichia coli cells) of antibacterial properties of the HA, silver-doped HA and silver layers was carried out. The best antibacterial results
were achieved for silver-doped HA layers of silver concentration higher than 1.2 at.%. |
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