Some bactericidal properties of oligopeptides and regular polypeptides including lysine and ornithine residues

Summary Oligopeptides and polypeptides of the sequences Lys₆-, Ala-Lys₄-Ala, Lys₈-, Orn₂-Ala₂-, Lys₃-Pro-, Lys₃-Gly-, Orn₃-Gly-, Lys-Pro-, Lys-Pro₂-, Lys₂-Pro-, Lys₃-Ala- possess bactericidal properties in relation to a strain of the bacteriumStaphylococcus aureus.It has been shown that with an increase in the amount of lysine and ornithine residues in the polypeptide chain the bactericidal properties increase; proline residues play a fundamental part in the manifestation of these properties.Institute of Molecular Biology, Academy of Sciences of the USSR, Moscow. Institute of Chemistry, Academy of Sciences of Tadzhik SSR, Dushanbe. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 130–133, January–February, 1978.