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A mild and expedient one-pot synthesis of substituted benzimidazoles in water using a phase-transfer catalyst |
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| Authors: | Manas Chakrabarty Sulakshana Karmakar Ratna Mukherjee Shiho Arima Yoshihiro Harigaya |
| Affiliation: | (1) Department of Chemistry, Bose Institute, 93/1, A. P. C. Road, Kolkata, 700009, India;(2) School of Pharmaceutical Sciences, Kitasato University, Minato-ku, Tokyo 108, Japan |
| Abstract: | Abstract 1-Alkyl/phenyl-2-arylbenzimidazoles have been synthesized in very good to excellent yields by a one-pot condensation of N-alkyl/phenyl-o-phenylenediamines with aryl aldehydes in water at room temperature using cetylpyridinium bromide as a cheap and eco-friendly catalyst. Graphical abstract  |
| Keywords: | Benzimidazoles Synthesis N-alkyl/phenyl-o-phenylenediamines Aryl aldehydes Phase-transfer catalyst |
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