Effect of Structure and Composition of Copper and Cobalt Complexes with Schiff Base Ligands on their DNA/Protein Interaction and Cytotoxicity |
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| Authors: | Peng Li Mao‐Fei Niu Mei‐Ju Niu Min Hong |
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| Institution: | Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology, School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252059, P. R. China |
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| Abstract: | Four transition metal complexes, namely Cu2Cl2(HL1)2 ( 1 ), Co(HL1)2 ( 2 ), Cu(HL2)2 ( 3 ), Co(HL2)3 ( 4 ) {H2L1 = 2‐{2‐(2‐hydroxy‐ethoxy)‐ethylimino]‐methyl}‐phenol, H2L2 = 3‐{2‐(2‐hydroxy‐ethoxy)‐ethylimino]‐methyl}‐naphthalen‐2‐ol} were synthesized and characterized by single‐crystal X‐ray diffraction, IR spectroscopy, and elemental analysis. The interactions of these copper and cobalt complexes with calf thymus DNA (CT‐DNA) were studied by absorption and emission titration spectroscopic methods. The interactions of these copper and cobalt complexes with bovine serum albumin (BSA) were also investigated using fluorescence, UV/Vis, and synchronous fluorescence spectroscopy. Further, the in vitro cytotoxic effect of the complexes are examined on human colon carcinoma cell lines (HCT‐116) and human lung carcinoma cell line (A549). |
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| Keywords: | Schiff bases Crystal structure DNA‐binding BSA‐binding In vitro cytotoxicity |
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