Nonenzymatic recombination of RNA by means of transesterification |
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| Authors: | A V Lutay I V Grigoriev M A Zenkova E L Chernolovskaya V V Vlassov |
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| Institution: | (1) Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 8 prosp. Akad. Lavrent’eva, 630090 Novosibirsk, Russian Federation |
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| Abstract: | Coupled nonenzymatic cleavage/ligation of oligoribonucleotides catalyzed by magnesium ions afforded longer RNA molecules with
a new sequence. The efficiency of formation of ligation products reaches 6%. The possible role of this reaction in the evolution
of the RNA world is discussed.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 12, pp. 2413–2419, December, 2007. |
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| Keywords: | oligoribonucleotides nonenzymatic ligation catalysis |
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