| Synthesis of 1-[(O,O-diphenyl phosphonyl)arylmethyleneamino carbonylmethyl]uracils |
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| 作者姓名： | Xue Jun LIU Guo Chen CHI Ru Yu CHEN |
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| 作者单位： | Institute and National Key Laboratory of Elemento-Organic Chemistry，Nankai UniversityTianjin 300071 |
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| 摘 要： | Recently,thederivativesofN-lpyrimidinesorN-9punnes,substitutedbyaphosphonylgroupwerefoundasanewclassofantiviralagentswithabroadspectrumofactivitiesagainstretrovirusesandDNAvirus"'.Andatthesametime,a-aminophosphonicacidsalsoexhibitvariousinterestingbiologicalactivities.Someofthemhavebeenemployedasanticancer,antibacterialandantibiotics'-'.Sowedesignedandsynthesizedthetitlecompoundsinordertosearchfornewbiologicallyactivitivesubstances.ThesyntheticrouteisshowninScheme1.Thekeyifltermediate2wasob…
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| 关 键 词： | Uracil. α-aminophosphonic acid. |
Synthesis of 1-[(O,O-diphenyl phosphonyl)arylmethyleneamino carbonylmethyl]uracils |
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| Xue Jun LIU, Guo Chen CHI, Ru Yu CHEN.Synthesis of 1-[(O,O-diphenyl phosphonyl)arylmethyleneamino carbonylmethyl]uracils[J].Chinese Chemical Letters,1999(9). |
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| Authors: | Xue Jun LIU Guo Chen CHI Ru Yu CHEN |
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| Abstract: | A new series of compounds,1-O,O-diphenyl phosphonyl)arylmethylene aminocarbo-nylmethyl]uracilsm,were synthesized in yield of 54.6-72.0% with DCC/BtOH as the couplingreagent,and their biological activities are being tested. |
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