| 制备2,4,6-三甲基苯甲醛的新方法 |
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| 引用本文： | 艾鑫淼,徐刚,吴坚平,杨立荣. 制备2,4,6-三甲基苯甲醛的新方法[J]. 合成化学, 2007, 15(3): 376-377 |
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| 作者姓名： | 艾鑫淼 徐刚 吴坚平 杨立荣 |
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| 作者单位： | 浙江大学,材料与化学工程学院,浙江,杭州,310027;浙江大学,材料与化学工程学院,浙江,杭州,310027;浙江大学,材料与化学工程学院,浙江,杭州,310027;浙江大学,材料与化学工程学院,浙江,杭州,310027 |
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| 摘 要： | 1,3,5-三甲苯与溴素在水溶液中反应生成2,4,6-三甲基溴苯(1,收率90%);1制备成格氏试剂再与甲醛反应得到2,4,6-三甲基苄醇(2,收率79%)。2经铬酸氧化得2,4,6-三甲基苯甲醛(3,收率90.3%)。3的总收率达64.2%,纯度97%。2和3的结构经1H NMR和MS确证。
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| 关 键 词： | 苯甲醛 溴化 格氏反应 合成 |
| 文章编号： | 1005-1511（2007）03-0376-02 |
| 收稿时间： | 2006-06-09 |
| 修稿时间： | 2006-06-09 |
A New Method for Preparing 2,4,6-Trimethylbenzaldehyde |
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| AI Xin-miao,XU Gang,WU Jian-ping,YANG Li-rong. A New Method for Preparing 2,4,6-Trimethylbenzaldehyde[J]. Chinese Journal of Synthetic Chemistry, 2007, 15(3): 376-377 |
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| Authors: | AI Xin-miao XU Gang WU Jian-ping YANG Li-rong |
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| Affiliation: | College of Material Science and Chemical Engineering, Zhejiang University, Hangzhou 310027, China |
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| Abstract: | 2,4,6-Trimethylbenzaldehyde(3) was synthesized from mesitylene via bromination,Grignard reaction and oxidation in an overall yield of about 64.2% with a purity of 97%.1,3,5Mesitylene reacted with bromine in water gaving 90% 1-bromo-2,4,6-trimethylbenzene(1),which was made into Grignard reagent and then reacted with formaldehyde to give 79% 2,4,6-trimethylbenzyl alcohol(2).2 was oxidated by chromic acid.The product was distilled giving 3 in yield of 90.3%.The structures of 2 and 3 were confirmed by 1H NMR and MS. |
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| Keywords: | benzaldehyde bromination Grignard reaction synthesis |
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