Glycomimetics and glycodendrimers as high affinity microbial anti-adhesins |
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Authors: | Imberty Anne Chabre Yoann M Roy René |
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Affiliation: | CERMAV CNRS/Université Joseph Fourier, Grenoble cedex 9, France. imberty@cermav.cnrs.fr |
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Abstract: | Adhesion to epithelial surface is often the first step in bacterial and viral infection. In this process, the microbes use a variety of proteins for interaction with host carbohydrates presented as glycoconjugates on cell surfaces. Crystal structures of adhesin and lectin binding sites in complexes with oligosaccharide open the route for design and synthesis of glycomimetics, glycodendrimers, and glycopolymers that are able to block infection at an early stage. |
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Keywords: | adhesin antiviral agents dendrimers glycomimetics lectins |
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