Determination and correlation of the solubility for diosgenin in alcohol solvents |
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| Institution: | 1. Sydney Medical School, The University of Sydney, Sydney, Australia;2. Discipline of Pathology, School of Medicine, Western Sydney University, Sydney, Australia;3. Centre for Oncology Education and Research Translation (CONCERT), Ingham Institute for Applied Medical Research, Sydney, Australia;4. Department of Anatomical Pathology, Sydney South West Pathology Service (SSWPS) Liverpool Hospital, Sydney, Australia;5. Bosch Institute, The University of Sydney, Sydney, Australia;6. Department of Head & Neck Surgery, Liverpool Hospital, Sydney, Australia;7. Faculty of Medicine, University of New South Wales, Sydney, Australia;8. Central Clinical School, University of Sydney, Sydney, Australia |
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| Abstract: | Using a laser monitoring technique, the solubility of diosgenin in ethanol, 1-propanol, 1-butanol, isobutyl alcohol, tert-butanol, 1-pentanol, and iso-octyl alcohol was measured over the temperature range from (290.15 to 330.15) K at atmospheric pressure. Its corresponding (solid + liquid) equilibrium data will provide essential support for industrial design and further theoretical studies. From the experimental results, the solubility of diosgenin in ethanol, 1-propanol, 1-butanol, isobutyl alcohol, tert-butanol, 1-pentanol, and iso-octyl alcohol was found to increase with increasing temperature and decrease with the increase of the polarity of the alcohols solvents. The Apelblat equation, the ideal model and the λh equation were used to correlate the solubility values. The results showed that the three models mentioned above agreed well with the experimental data. |
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