The buffering-out effect and phase separation in aqueous solutions of EPPS buffer with 1-propanol, 2-propanol,or 2-methyl-2-propanol at T = 298.15 K |
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| Affiliation: | 1. Department of Neurosurgery, Graduate School of Medicine, Gifu University, Gifu, Japan;2. Department of Neurosurgery, Graduate School of Medicine, Hyogo Collage of Medicine, Hyogo, Japan;1. Department of Materials Science and Engineering, Norwegian University of Science and Technology, NO-7491 Trondheim, Norway;2. Department of Chemistry, University of Victoria, Victoria, British Columbia V8W 3V6, Canada;1. Key Laboratory of Colloid and Interface Chemistry, Shandong University, Ministry of Education, Jinan 250100, China;2. Laboratory of Environmental Sciences and Technology, Xinjiang Technical Institute of Physics & Chemistry, Key Laboratory of Functional Materials and Devices for Special Environments, Chinese Academy of Sciences, Urumqi 830011, China;1. School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116024, China;2. William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, 151 West Woodruff Avenue, Columbus, OH 43210, USA;3. School of Bioscience and Bioengineering, South China University of Technology, Guangzhou 510006, China |
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| Abstract: | Buffering-out is a new liquid–liquid phase separation phenomenon observed in mixtures containing a buffer as a mass separating agent. The (liquid + liquid) equilibrium (LLE) and (solid + liquid + liquid) equilibrium (SLLE) data were measured for the ternary systems {3-[4-(2-hydroxyethyl)piperazin-1-yl]propanesulfonic acid (EPPS) buffer + 1-propanol, 2-propanol, or 2-methyl-2-propanol + water} at T = 298.15 K under atmospheric pressure. The phase boundary data were fitted to an empirical equation relating to the concentrations of organic solvent and buffer. The effective excluded volume (EEV) values of EPPS were obtained from the phase boundary data. The phase-separation abilities of the investigated aliphatic alcohols were discussed. The reliability of the experimental tie-lines was satisfactorily confirmed by the Othmer–Tobias correlation. The experimental tie-lines data for the ternary systems have been correlated using the NRTL activity coefficient model. The separation of these aliphatic alcohols from their azeotropic aqueous mixtures is of particular interest to industrial process. The addition of the EPPS as an auxiliary agent breaks the (1-propanol + water) and (2-methyl-2-propanol + water) azeotropes. The possibility of using the new phase separation systems in the extraction process is demonstrated by using different dyestuffs. |
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