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Solubility of diosgenin in different solvents
Institution:1. School of Chemical Engineering and Energy, Zhengzhou University, Zhengzhou, Henan 450001, China;2. Henan Medical College for Staff and Workers, Zhengzhou, Henan 451191, China;1. CSIR-Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP), Kukrail Picnic Spot Road, P.O. CIMAP, Lucknow 226015, India;2. CSIR-Central Drug Research Institute (CSIR-CDRI), B.S. 10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India;3. Department of Chemistry, University of Ilorin, Ilorin, Nigeria;4. Organic Chemistry Unit, Department of Chemistry, University of Ibadan, Ibadan, Nigeria;1. Department of Chemistry, Graduate School of Science, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka 560-0043, Japan;2. ERATO, Lipid Active Structure Project, Japan Science and Technology Agency, 1-1 Machikaneyama, Toyonaka, Osaka 560-0043, Japan;1. Department of Pharmacy, Cosmetic Chemistry and Biotechnology, Team of Chemistry, Łukasiewicz Research Network–Industrial Chemistry Institute, 8 Rydygiera Str., 01–793 Warsaw, Poland;2. Department of Lipids and Liposomes, Faculty of Biotechnology, University of Wrocław, 14a Joliot–Curie Street, 50–383 Wrocław, Poland;3. Institute of Organic Chemistry Polish Academy of Sciences, 44/52 Kasprzaka Str., 01–224 Warsaw, Poland;4. Analytical Department, Łukasiewicz Research Network–Industrial Chemistry Institute, 8 Rydygiera Str., 01–793 Warsaw, Poland;5. Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, 02–093 Warsaw, Poland;1. Biochemistry, Molecular Endocrinology, and Reproductive Physiology Laboratory, Department of Human Physiology, Vidyasagar University, Midnapore, West Bengal, Pin-721102, India;2. Department of Surgery, College of Medicine, the University of Illinois at Chicago, Chicago, IL, 60612, USA;3. Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, West Bengal, India
Abstract:The solubility of diosgenin in methanol, ethanol (95%), isopropanol, acetone, acetic ether, and propyl acetate were measured at temperatures from (295.15 to 330.15) K using the synthetic method by a laser monitoring observation technique at atmospheric pressure. Its corresponding (solid + liquid) equilibrium data will provide essential support for industrial design and further theoretical studies. The solubility data of diosgenin in isopropanol, acetone, ethanol (95%), and acetic ether were correlated with Apelblat equation, and the experimental data of diosgenin in methanol and propyl acetate were also correlated with the λh model. The calculated values were good in agreement with the experimental values.
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