| 单倍型异基因造血干细胞-脐带间充质干细胞联合移植治疗1例急性白血病 |
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| 引用本文： | 徐丽昕,马健,曹永彬,王志红,刘蓓,闫蓓,刘周阳,达万明,吴晓雄.单倍型异基因造血干细胞-脐带间充质干细胞联合移植治疗1例急性白血病[J].压电与声光,2010(2):200-200,F0003. |
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| 作者姓名： | 徐丽昕 马健 曹永彬 王志红 刘蓓 闫蓓 刘周阳 达万明 吴晓雄 |
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| 作者单位： | 解放军总医院第304临床部血液科,北京100048 |
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| 摘 要： | 目的研究急性粒细胞白血病异基因造血干细胞-人脐带源间充质干细胞（hUG—MSC）联合移植效果。方法急性髓性白血病-M2，供者为其胞兄，HLA单倍型相合，移植物为经粒细胞集落刺激因子（Granulocyte Clony—Stimulating Factor，G—CSF）动员的骨髓以及外周血造血干细胞，加入分离、扩增的hUC—MSC。移植物抗宿主病（Graft—Versus—Host Disease，GVHD）预防采用环孢菌素A＋ATG^＋霉酚酸酯＋短程甲氨喋呤和CD25单抗。结果输注供者的MSC总数和CD34细胞数分别为7．92×10^8/L和3．78×10^6／L。中性粒细胞大于0．5×10^9／L和血小板大于20×10^9／L的时间分别为14d和15d。24d嵌合体100％，40d左右出现Ⅰ度aGVHD，治疗后好转，未出现其他严重并发症。结论异基因造血干细胞-人脐带源间充质干细胞（hUC—MSC）联合移植安全简便，可加速造血功能恢复。
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| 关 键 词： | 造血干细胞移植 联合移植 白血病 |
Transplantation of combined haplo-hematopoietic and human umbilical cord-derived mesenchymal stem cells for acute leukemia:A case report |
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| XU Li-xin,MA Jian,CAO Yong-bin,WANG Zhi-hong,LIU Bei,YAN Bei,LIU Zhou-yang,DA Wan-ming,WU Xiao-xiong.Transplantation of combined haplo-hematopoietic and human umbilical cord-derived mesenchymal stem cells for acute leukemia:A case report[J].Piezoelectrics & Acoustooptics,2010(2):200-200,F0003. |
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| Authors: | XU Li-xin MA Jian CAO Yong-bin WANG Zhi-hong LIU Bei YAN Bei LIU Zhou-yang DA Wan-ming WU Xiao-xiong |
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| Institution: | XU Li-xin,MA Jian,CAO Yong-bin,WANG Zhi-hong,LIU Bei,YAN Bei,LIU Zhou-yang,DA Wan-ming,WU Xiao-xiong Department of Hematology,304 Clinical Division,Chinese PLA General Hospital,Beijing 100048,China |
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| Abstract: | Objective To investigate the effect of combined transplantation of human umbilical cord derived mesenchymal stem cells(hUC-MSCs)and hematopoietic stem cells on acute myloid leukemia.Methods The patient with acute myloid leukemia received marrow and peripheral blood stem cell transplantation(UD-PBSCT)with granulocyte clony-stimulating factor(G-CSF).hUC-MSCs were isolated,culture-expanded from human umbilical cord after enzyme digestion,and cotransplantation to patient with haplo-hematopoietic stem cells.The ... |
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| Keywords: | Hematopoietic Stem Cell Transplantation Cotransplantation Leukemia |
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