Indole derivatives. 120. Synthesis of higher ω-(3-indolyl)alkanoic acids by alkylation of indole lactones

The alkylation of indole with the tridecanolide, pentadecanolide, and oxo lactones of ω-hydroxyethoxyundecanoic and ω-hydroxybutoxyundecanoic acids was investigated. Higher indolylalkanoic acids, viz., ω-(3-indolyl)undecanoic, ω-(3-indolyl)tride-canoic, and ω-(3-indolyl)pentadecanoic acids, were obtained. The scheme of the alkylation of indole with oxo lactones, and the difference in the rates of the reactions of the ester and lactone bonds, were established from the reaction products. See [1] for communication 119. Translated from Khimiya Getetotsiklicheskikh Soedinenii, No. 2, pp. 216–217, February, 1980.