| 7-氨基喹唑啉的合成 |
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| 引用本文： | 李久明,雍建平. 7-氨基喹唑啉的合成[J]. 光谱实验室, 2010, 27(5): 1814-1816 |
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| 作者姓名： | 李久明 雍建平 |
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| 作者单位： | 内蒙古民族大学化学化工学院,内蒙古通辽市西拉木仑大街996号,028043;宁夏医科大学公共卫生学院,银川市兴庆区胜利街1160号,750004 |
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| 摘 要： | 7-氨基喹唑啉是合成杂环药物的重要中间体。为了寻找经济的合成7-氨基喹唑啉的方法,本文以Pd/C和Zn粉共同作用还原4-氯-7-硝基喹唑啉制备7-氨基喹唑啉,产率达到52%。比文献报道的产率略高,最关键的是与文献报道的直接用Pd/C还原的方法相比较,此法更经济。
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| 关 键 词： | 合成 7-氨基喹唑啉 Pd/C和Zn还原反应 |
Synthesis of 7-Amino-Quinazoline |
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| LI Jiu-Ming,YONG Jian-Ping. Synthesis of 7-Amino-Quinazoline[J]. Chinese Journal of Spectroscopy Laboratory, 2010, 27(5): 1814-1816 |
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| Authors: | LI Jiu-Ming YONG Jian-Ping |
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| Affiliation: | LI Jiu-Ming YONG Jian-Pinga(College of Chemistry and Chemical Engineering,Inner Mongolia University for the Nationalities,Tongliao,Inner Mongolia 028043,P.R.China)a(School of Public Health in Ningxia Medical University,Yinchuan 750004,P.R.China) |
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| Abstract: | 7-amino-quinazoline is an important intermediate for synthesizing the heterocyclic drugs.In order to find an economical method to synthesize the 7-amino-quinazoline,7-amino-quinazoline was synthesized from reduction of 4-choloro-7-nitro-quinazoline with Pd/C and Zn,and the yield is 52%,which is little higher than the method has been reported.The method is more economical than the method only using Pd/C as reducer. |
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| Keywords: | Synthesis 7-Amino-Quinazoline Reduction Reaction with Pd/C and Zn |
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