Heterocycles [h]-fused to 4-oxoquinoline-3-carboxylic acid. Part VII: synthesis of some 6-oxoimidazo[4,5-h]quinoline-7-carboxylic acids and esters |
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| Authors: | Maram R. Al-Dweik Jalal A. Zahra Monther A. Khanfar Mustafa M. El-Abadelah Klaus-Peter Zeller Wolfgang Voelter |
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| Affiliation: | (1) Chemistry Department, Faculty of Science, University of Jordan, Amman, Jordan;(2) Institut f?r Organische Chemie, Universit?t T?bingen, T?bingen, Germany;(3) Interfakult?res Institut f?r Biochemie, Universit?t T?bingen, Hoppe-Seyler Str. 4, 72076 T?bingen, Germany; |
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| Abstract: | Abstract A series of ethyl 2-(substituted)-9-cyclopropyl-4-fluoro-6-oxo-1H-imidazo[4,5-h]quinoline-7-carboxylates has been prepared from ethyl 7,8-diamino-1,4-dihydroquinoline-3-carboxylate via thermally induced reactions with model alkanoic acids or via microwave-assisted cyclocondensation with some arene carboxaldehydes. Acid-catalysed hydrolysis of the resulting ester derivatives furnished the corresponding imidazoquinoline-7-carboxylic acids. The structures of these new acid and ester derivatives are based on microanalytical and spectral (IR, MS, and NMR) data. |
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