Stereoselective furan-iminium cation cyclization in the construction of the core structure of manzamine A |
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Authors: | Tokumaru Kazuyuki Arai Shigeru Nishida Atsushi |
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Institution: | Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi-cho, Inage-ku, Japan. |
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Abstract: | reaction: see text] A new type of furan-iminium cation cyclization was developed and used to construct the ABC ring of manzamine A. The cyclization proceeded at the 2-position with complete regio- and stereoselectivity to give a spiro-center. The product was efficiently converted to the highly substituted core structure of manzamine A. |
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