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UNUSUALLY HIGH AFFINITY OF Zn(II)-TETRADIBENZOBARRELENOOCTABUTOXY- PHTHALOCYANINE FOR LOW-DENSITY LIPOPROTEINS IN A TUMOR-BEARING MOUSE |
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| Authors: | M Soncin L POLO E REDDI G JORI B D RIHTER M E KENNEY M A J RODGERS |
| Institution: | Department of Biology, University of Padova, Via Trieste 75,35121 Padova, Italy;Department of Chemistry, Case, Western Reserve University, Cleveland, OH 44106;Center for Photochemical Sciences, Bowling Green State University, Bowling Green, OH 43403 |
| Abstract: | Abstract— An important factor in determining the efficacy of photosensitizing compounds in photodynamic therapy of tumors is the level to which tumors take up the photosensitizers after systemic injection. This parameter seems to be related to the transport modalities of the photosensitizer in the bloodstream. In this work the photosensitizer Zn(II)-tetradibenzobarreleno-octabutoxyphthalocyanine was shown to have an unprecedentedly high association with low-density lipoproteins (71% of the phthalocyanine in the plasma) when delivered in Cremophor micelles to tumor-bearing mice. This was accompanied by a particularly high tumor uptake at 24 h post-injection. |
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