A new class of non-racemic chiral macrocycles: a conformational and synthetic study |
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Authors: | Gibson Susan E Mainolfi Nello Kalindjian S Barret Wright Paul T White Andrew J P |
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Affiliation: | Department of Chemistry, Imperial College London, South Kensington Campus, London SW7 2AY, UK. s.gibson@imperial.ac.uk |
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Abstract: | Amino alcohols have been used to introduce non-racemic chirality into macrocycles using a modular approach that relies on a Heck macrocyclisation reaction. A wide variety of macrocycles have been synthesised, and their structures studied using X-ray crystallography and molecular modelling. A fragmentation reaction encountered during the use of (S)-1,1-dimethylvalinol revealed that carboxylic acids generate acylals under reaction conditions often used for Heck reactions. |
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