Asymmetric transfer hydrogenation of aromatic ketones by Rh(I)/bimorpholine complexes |
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| Institution: | 1. Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China;2. Department of Clinical Pharmacy, Taizhou Hospital, Zhejiang, Linhai 317000, China;3. College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, Zhejiang 325035, China;4. Institute of Sports Science, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China;1. The Key Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Laboratory of Molecular-Based Materials (State Key Laboratory Cultivation Base), College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241002, China;2. State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Science, Fuzhou 350002, China |
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| Abstract: | The asymmetric hydride transfer reduction of aromatic ketones, using a Rh(cod)Cl]2 complex as a catalyst and (3S,3′S)-bimorpholine as a chiral ligand, was studied. By varying the amount of ligand, basic co-catalyst and temperature, high yields (>90%) and good enantiomeric excesses of the alcohols (ee up to 83%) were achieved. |
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