Pore dynamics of osmotically stressed vesicles |
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| Institution: | 1. Dept. of Physics Govt Arts & Science College, Veppanthattai – 621116, Perambalur Dist, Tamilnadu, India;2. Dept. of R&D, Edayathangudy G.S. Pillay Arts and Science College, Nagapattinam 611002, Tamilnadu, India;3. P.G & Research Dept. of Physics, Edayathangudy G.S Pillay Arts & Science College, Nagapatinam-611002, Tamilnadu, India;4. Dept. of Physics, Syed Ammal Engineering College, Ramanathapuram - 623502, Tamilnadu, India;1. Laboratory of Lymphocyte Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA;2. The Rockefeller Graduate Program, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA;3. Current address: Department of Biology, Harvey Mudd College, 301 Platt Bvd, Claremont, CA 91711, USA;1. Burn Injuries Task Area, United States Army Institute of Surgical Research, 3698 Chambers Pass, San Antonio Military Medical Center, Fort Sam Houston, TX 78234, United States;2. US Army Medical Research and Materiel Command, USACEHR, Fort Detrick, MD 21702-5010, United States;1. Department of Chemistry, School of Pharmaceutical Sciences, GuangZhou Medical University, GuangZhou 510182, PR China;2. College of Materials, Xiamen University, Xiamen 361005, PR China |
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| Abstract: | We present a theory for pore dynamics of osmotically stressed vesicles. When a liposome with an internal concentration of solute is placed inside a solute-depleted medium, an osmotic flow of solvent through the lipid bilayer leads to swelling of vesicle and to increase in membrane surface tension. This can result in membrane rupture and opening of thermal pores. Depending on the internal concentration of solute and the size of the vesicle, pores can close rapidly or be long lived. We find that the life span of the long-lived pores scales non-trivially with the size of the liposome. Closure of the long-lived pore is followed by a rapid flicker-like opening and closing of short-lived pores. Our model is consistent with the observation of long-lived pores in red blood cell ghosts. |
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