Diffusion of levodopa in aqueous solutions of hydrochloric acid at 25 °C |
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| Institution: | 1. Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade de Coimbra, 3004-535 Coimbra, Portugal;2. U.D. Química Física, Universidad de Alcalá, 28871 Alcalá de Henares, Madrid, Spain;3. Department of Chemistry, St. Francis Xavier University, Antigonish, Nova Scotia B2G 2W5, Canada;1. Centre for Earth, Planetary, Space and Astronomical Research CEPSAR, The Open University, Milton Keynes, UK;2. Life, Health and Chemical Sciences, The Open University, Milton Keynes, UK;3. Institute of Microbiology and Infection, University of Birmingham, Edgbaston, Birmingham, UK;4. London School of Hygiene & Tropical Medicine, London, UK;5. Biomedical Research and Training Institute, Harare, Zimbabwe;1. Centro de Investigação em Química and Faculdade de Ciências, University of Porto, 4169 007 Porto, Portugal;2. INFU, Faculty of Chemistry, Technical University of Dortmund, Otto-Hahn-Str. 6, D-44221 Dortmund, Germany;3. Department of Biomedical Sciences, Faculty of Health and Society, Malmö University, Malmö högskola, 205 06 Malmö, Sweden |
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| Abstract: | Ternary mutual diffusion coefficients (D11, D22, D12 and D21) measured by the Taylor dispersion method are reported for aqueous solutions of {levodopa (l-dopa) + HCl} solutions at 25 °C and HCl concentrations up to 0.100 mol · dm−3. The coupled diffusion of l-dopa (1) and HCl (2) is significant, as indicated by large negative cross-diffusion coefficients. D21, for example, reaches values that are larger than D11, the main coefficient of l-dopa. Combined Fick and Nernst–Planck equations are used to analyze the proton coupled diffusion of l-dopa and HCl in terms of the binding of H+ ions to l-dopa and ion migration in the electric field generated by l-dopa and HCl concentration gradients. |
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| Keywords: | Levodopa Diffusion coefficient Transport properties Aqueous solutions |
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