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Simultaneous dehalogenation and hydrogenation reduction of halogen-heteroaromatic aldehydes |
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| Authors: | Xi-Bo Chen Qiu-Peng Hu Qian-Jia Yuan Wei Ding Jiangmeng Ren Bu-Bing Zeng |
| Affiliation: | a School of Pharmacy, East China University of Science and Technology, Shanghai 200237, PR China b Shanghai Key Laboratory of Chemical Biology, Shanghai 200237, PR China c Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, PR China |
| Abstract: | Treatment of halogen-heteroaromatic aldehydes with catalytic amount of PdCl2 under atmosphere pressure of hydrogen in base medium (sodium acetate) leads to the corresponding dehalogenated primary alcohols. The reaction system was especially effective for the heteroaromatic compounds bearing aldehyde groups and halides (bromo- or chloro-functions). |
| Keywords: | Halogen-heteroaromatic aldehydes Palladium catalysts Hydrogen Dehalogenation Hydrogenation |
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