Synthesis of 3,4-dihydropyrimidin-2(1H)-one via Retro-Biginelli reaction |
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| Authors: | Sudipta Mondal Mohabul A. Mondal |
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| Affiliation: | Department of Chemistry, Jadavpur University, Kolkata, India |
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| Abstract: | Hydrolytic behavior of 5-acetyl-6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one under alkaline condition has been explored. Mechanistic details are established by LCMS and HPLC. Evidence suggested that the deacetylative benzylidenation proceeds through the retro-Biginelli reaction. The scope of the retro-Biginelli reaction has been explored by the synthesis of substituted DHPs. |
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