Synthesis,characterization, and antioxidant and anticholinesterase activities of pyrazolo derivatives |
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| Authors: | Yusuf Sicak Emine E. Oruç-Emre Mehmet Öztürk Ayşegül Karaküçük-İyidoğan Said Nadeem |
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| Affiliation: | 1. Department of Medicinal and Aromatic Plants, Köyceğiz Vocational School, Muğla Sıtkı Koçman University, Muğla, Turkey;2. Department of Chemistry, Faculty of Science and Arts, Gaziantep University, Gaziantep, Turkey;3. Department of Chemistry, Faculty of Science, Muğla Sıtkı Koçman University, Muğla, Turkey;4. Department of Food Processing, Köşk Vocational School, Aydın Adnan Menderes University, Aydın, Turkey |
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| Abstract: | Twenty-four pyrazolo derivatives (1–4)(a-f) were synthesized and characterized by FTIR, 1H, and 13C NMR (Nuclear Magnetic Resonance), and elemental analysis. The synthesized compounds were also investigated for their antioxidant and anticholinesterase activities. The compounds (3–4)(a-f) carrying morpholine ring were more active than the piperidinyl containing compounds (1–2)(a-f) in both activities. The compound 4f showed higher activity in both assays as compared with the others. Additionally, the anticholinesterase activity test provided higher values than the galantamine in the BChE assay. Therefore, compound 4f can be used as anticholinesterase agent and/or anticholinesterase assay standard. |
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