Synthesis,characterization, and antimicrobial evaluation of some novel anthracene heterocycles derivatives |
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| Authors: | Hemat M. Dardeer Ahmed G. Taha Rokaya B. Elamary |
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| Affiliation: | 1. Chemistry Department, Faculty of Science, South Valley University, Qena, Egypt;2. Botany and Microbiology Department, Faculty of Science, South Valley University, Qena, Egypt |
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| Abstract: | A series of novel heterocyclic compounds containing anthracene moiety was synthesized. Reaction of (11R,15S)-9,10-dihydro-9,10-[3,4]furanoanthracene-12,14-dione with 2-cyanoacetohydrazide gave 2-cyano-pyrroloanthracen acetamide (1) , which acts as an adaptable material for the synthesis of new heterocyclic compounds. The synthesized compounds were examined for their antimicrobial activity against Escherichia coli and Staphylococcus aureus via p-iodonitrotetrazolium violet formazon assay. The results exhibited great activity against the tested strains with a minimum bactericidal concentration range from 0.636 to 3.8 mg/mL) and 0.159 to 3.6 mg/mL for E coli and S aureus, respectively. Interestingly, the highest activity was recorded for chromene derivative (6) against both strains. |
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