Synthesis and in vitro evaluation of novel tetralin-pyrazolo[3,4-b]pyridine hybrids as potential anticancer agents |
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| Authors: | Eman Kh Hamza Nehal A Hamdy Eman S Zarie Issa MI Fakhr Ahmed HM Elwahy Hanem M Awad |
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| Institution: | 1. Applied Organic Chemistry Department, National Research Centre, Giza, Egypt;2. Pharmaceutical and Drug Industries Research Division, Therapeutic Chemistry Department, National Research Centre, Giza, Egypt;3. Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt;4. Department of Tanning Materials and Leather Technology, National Research Centre, Cairo, Egypt |
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| Abstract: | New hybrids of tetralin-pyrazolo3,4-b]pyridine were synthesized in good yields. The structures of newly synthesized compounds were confirmed by IR, NMR, MS, and elemental analyses. Some of the new compounds were in vitro evaluated as antiproliferative candidates against two human cancer cell lines (HCT116 and MCF-7). Most of the examined derivatives showed promising anticancer activity. |
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