A facile one-step synthesis of chromeno[4,3-b]pyridine derivatives promoted by niobium pentachloride |
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| Authors: | Paula B Oshiro Bruna A Bregadiolli Luiz C da Silva-Filho |
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| Institution: | 1. Department of Chemistry, School of Sciences, São Paulo State University (UNESP), São Paulo, Brazil;2. Chemistry Institute, São Paulo State University (UNESP), São Paulo, Brazil |
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| Abstract: | Chromenes are part of an important class of heterocyclic compounds, natural or synthetic, and have many biological and chemical applications. Among them, chromenopyridines has arisen as a promising material for pharmacological applications. In this work is described a simple and cost-effective method to synthesize chromeno4,3-b]pyridine derivatives from multicomponent reaction between 4-aminocoumarin, benzaldehyde derivatives, and ethyl benzoylacetates catalyzed by niobium pentachloride. The new method provides good yields with reasonable reaction times, under mild reaction conditions. |
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