Efficient reactions for the synthesis of pyrazolo[3,4-b]pyridine and pyrano[2,3-c]pyrazole derivatives from N-methyl-1-(methylthio)-2-nitroethen-1-amine |
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| Authors: | Yifan Ji Li Li Guangzhou Zhu Ya Zhou Xinchi Lu Wenjing He Lijiu Gao Liangce Rong |
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| Affiliation: | 1. Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials;2. School of Chemistry and Materials Science, Jiangsu Normal University, Xuzhou, China |
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| Abstract: | The efficient and novel method for the synthesis of pyrazolo[3,4-b]pyridine and pyrano[2,3-c]pyrazole derivatives from the multicomponent reaction of aromatic aldehydes (isatins), N-methyl-1-(methylthio)-2-nitroethen-1-amine, and 3-aminopyrazole or methyl 3-hydroxy-1H-pyrazole-5-carboxylate under normal laboratory conditions was reported in this research. The advantages of this research are wide range of substrates, high yields, and simple operation. |
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