Synthesis,reactions, and spectral characterization of some new biologically active compounds derived from thieno[2,3-c]pyrazole-5-carboxamide |
| |
Authors: | Ahmed F. Saber Remon M. Zaki Adel M. Kamal El-Dean Shaban M. Radwan |
| |
Affiliation: | Chemistry Department, Faculty of Science, Assiut University, Assiut, Egypt |
| |
Abstract: | The starting compound 4-amino-3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide (1) , that has been previously synthesized according to the literature procedure, underwent a reaction with the anhydride of phthalic acid either in AcOH or DMF to give isoindolinylpyrazole-5-carboxamide 3 and pyrazolothienopyrimidoisoindoledione 4 , respectively. Also, it was subjected to react with diethylmalonate followed by hydrazinolysis by hydrazine hydrate to yield the pyrazolothienopyrimidinyl acetohydrazide 5 . The carbohydrazide derivative 5 was used as a key intermediate for the preparation of other new heterocyclic systems containing pyrazolylacetyl pyrazolothienopyrimidines and pyrazolothieno-pyrimidotriazepine compounds 6–11 . The structures of these new heterocycles have been characterized by using analytical and spectroscopic analyses (IR, 1H-NMR, 13C-NMR and MS). Some derivatives of the synthesized compounds exhibited remarkable antibacterial and antifungal activities against many bacterial and fungal strains. |
| |
Keywords: | |
|
|