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New cytotoxic bio-transformed sesquiterpene by Rhizopus oryzae fungus |
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| Authors: | Abeer Abas Abd El Aty Naglaa Salah El-Deen Mohamed Ibrahim Ahmed Saleh Ahmed Atef El-Beih Mohamed Helmy Abdelrazik Taha Abdelrahim Hussien Mahmoud Moustafa |
| Institution: | 1. Chemistry of Natural and Microbial Products Department, National Research Centre, Giza, Egypt
Biology Department, Faculty of Education, Hafr Al Batin University, Hafr Al Batin, Saudi Arabia;2. Faculty of Science, Chemistry Department, Aswan University, Aswan, Egypt;3. Phytochemistry Department, National Research Centre, Giza, Egypt;4. Chemistry of Natural and Microbial Products Department, National Research Centre, Giza, Egypt;5. Natural Compounds Chemistry Department, National Research Centre, Giza, Egypt;6. Pharmacognosy Department, Faculty of Pharmacy, Deraya University, El-Minia, Egypt;7. Department of Biology, College of Science, King Khalid University, Abha, Saudi Arabia Department of Botany, Faculty of Science, South Valley University, Qena, Egypt |
| Abstract: | Due to the rapidly increasing number of pathogenic bacteria, viruses, and tumor cells that possess resistance toward established therapies, lead structures for the development of new drugs are in high demand. The plant material of Tanacetum sinaicum is considered a prolific source of the potent biologically active sesquiterpene Tanacetolide A ( 1 ). In our research, we focused on the structural transformation of the substrate Tanacetolide A (compound 1 ) by suspended culture of the novel locally isolated terrestrial fungus Rhizopus oryzae KX685359. The fungal transformation resulted in the formation of 1β,3α-dihydroxy-6α-hydroperoxy-eudsm-4(15)-ene 12-oic acid ( 2 ) with higher antiproliferative activity against colon cancer cell line (Caco-2) than that of the parent compound ( 1 ). |
| Keywords: | Antiproliferative fungal transformation Rhizopus oryzae KX685359 Tanacetolide A Tanacetum sinaicum |