Three-component one-pot synthesis of pyrazino[2,3-a]acridine derivatives under catalyst-free conditions |
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| Authors: | Jia-Yan Liu Jin-Xing Xu Xiao-Ming Qiao Ya Cai Dong-Sheng Chen |
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| Affiliation: | Kangda College of Nanjing Medical University, Lianyungang, P. R. China |
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| Abstract: | A new series of pyrazino[2,3-a]acridine derivatives were prepared, via three-component reaction of quinoxalin-6-amine, aromatic aldehydes and 5,5-dimethyl cyclohexane-1,3-dione or cyclohexane-1,3-dione in ethanol as a solvent at reflux. The advantages of this protocol include mild reaction conditions, easy purification, high yields, and catalyst-free approach. |
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