Design and synthesis of diethyl(substituted 2-benzylbenzofuran-3-yl)phosphonates as antioxidant and antimicrobial agents |
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| Authors: | Mohan Gundluru Santhisudha Sarva Murali Sudileti Sreekanth Tellamekala Subba Rao Yakkate Bakthavatchala Reddy Nemallapudi Suresh Reddy Cirandur |
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| Institution: | 1. Department of Chemistry, Sri Venkateswara University, Tirupati, A.P, India;2. DST-PURSE Centre, Sri Venkateswara University, Tirupati, A.P, India;3. Chemical Engineering Institute, Ural Federal University, Yekaterinburg, Russia |
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| Abstract: | In continuance of our effort to improve novel and potent synthetic approaches for various bioactive phosphorylated heterocycles via C─P bond formation, a series of diethyl substituted(2-benzylbenzofuran-3-yl)phosphonate derivatives ( 4a - j ) was synthesized by one-pot reaction of various diversely substituted salicylaldehydes, phenyl acetylene, and diethyl phosphite using CuO nanoparticles as catalyst in 1:1 ethanol and water under room temperature. The new compounds have been studied for their radical scavenging activity by DPPH, H2O2, and NO approaches and antimicrobial activity assay against bacteria and fungi by disk diffusion method. |
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