Mechanochemical synthesis of 5-acetylthiazole: A step toward green and sustainable chemistry |
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| Authors: | Abdullah S. Al-Bogami Tamer S. Saleh Adel H. Al-Shareef |
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| Affiliation: | Department of Chemistry, College of Science, University of Jeddah, Jeddah, Saudi Arabia |
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| Abstract: | Mechanochemical synthesis of 5-acetylthiazole derivatives by one-pot three-component procedure over Silica Sulfuric acid under solvent-free conditions, has been developed. The durability of the catalyst was tested. The environmentally benign protocol introduced herein characterized by no hazardous organic solvent used, recyclability of the catalyst up to five runs without loss of its catalytic activity and high yields of products that confirm the utilization of some green chemistry principles in the mentioned protocol. |
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